1．基本信息
徐晖，男，1973年4月生，浙江余姚人，三级教授，博士生导师。宁波大学学士、西北农林科技大学硕士、浙江大学博士、巴黎十一大药物化学博士后。曾在江苏扬子江药业集团担任课题组长从事药物研发。2005年7月聘为西北农林科技大学副教授、硕士生导师。2008年晋升教授及聘为博士生导师， 2011年至今聘为三级教授。现为中国植物保护学会植物化感作用专业委员会副主任委员、中国化工学会农药专业委员会委员、中国植保学会农药学分会委员。重要药物化学刊物 Mini-Reviews in Medicinal Chemistry 及《农药学学报》的编委。以第一完成人于2017年获陕西省高等学校科技奖一等奖及陕西省科学技术奖二等奖各1项。
2006年入选教育部新世纪优秀人才支持计划，2007年获第三届杨凌十大杰出青年称号，2008年获陕西省青年突击手称号, 2009年获陕西省优秀留学回国人员称号，同年及获第十二届中国药学会-施维雅青年药物化学奖。2010年获第九届“陕西青年五四奖章”提名奖,同年及获霍英东青年教师基金奖项。2011年获陕西省高校优秀共产党员称号。2009年被ELSEVIER授予 Bioorg. Med. Chem. Lett. “Most Cited Paper 2006-2009 Award”。 2005年7月参加工作以来，先后共主持国家自然科学基金面上项目、教育部重点等10余项国家及省部级科研项目；以第一(通讯)作者先后在 Chem. Eur. J., J . Agric . Food Chem. , ACS Sust. Chem. Eng., Curr. Med. Chem., Eur. J. Med. Chem., J . Ind . Eng . Chem ., Curr. Top. M ed. C hem., M ini -R ev. M ed. C hem. 等刊物上全文发表SCI论文100余篇。担任SCI 国际期刊 Mini-Reviews in Organic Chemistry 的客座编辑 (Outline: Natural Products as Leads for New Drugs and Pesticides Discovery )于2012年5月出版。
2．研究方向
1）、基于植物源农用活性化合物为先导的结构优化，构效关系及作用机理研究；
2）、具农用生物活性杂环化合物的合成及构效研究。
3．开设课程
先后承担本科生《药物化学》、《有机化学实验》、《有机合成》、《综合化学实验》、《天然产物化学研究进展》和《有机立体化学》双语课程；为博、硕士研究生讲授《有机合成和设计》、《药物化学》、《农药科学新进展》和《农药分子设计》。
目前已培养博士研究生15名、硕士研究生45名。
4．近些年来课题组发表的代表性研究论文（西农第一单位、第一(通讯)作者）：
1) Xu Hui*; Xu, Ming; Sun, Zhiqiang, Li, Shaochen. Preparation of Matrinic/Oxymatrinic Amide Derivatives as Insecticidal/Acaricidal Agents and Study on the Mechanisms of Action against Tetranychus cinnabarinus . J ournal of A gricultural and F ood C hemistry , 2019, 67, 12182-12190.
2) Huang, Xiaobo; Lv, Min*; Xu Hui*. Semisynthesis of novel N-acyl/sulfonyl derivatives of 5(3,5)-(di)halogenocytisines/cytisine and their pesticidal activities against Mythimna separata Walker, Tetranychus cinnabarinus Boisduval, and Sitobion avenae Fabricius . Pest Management Science , 2019, 75, 2598-2609.
3) Li Shaochen, Sun Zhiqiang, Zhang Bingchuan, Lv Min*, Xu Hui*. Non-food bioactive products: Semisynthesis, biological activities, and mechanisms of action of oximinoether derivatives of matrine from Sophora flavescens. Industrial Crops and Products , 2019, 131，134-141.
4) Xu Ming, Xu Jianwei, Hao Meng, Zhang Kong, Lv Min*, Xu Hui*. Evaluation of andrographolide-based analogs derived from Andrographis paniculata against Mythimna separata Walker and Tetranychus cinnabarinus Boisduval. Bioorganic Chemistry , 2019, 86: 28-33.
5) Zhang Bingchuan, Sun Zhiqiang, Lv Min, Xu Hui*. Semisynthesis of Matrinic Acid/Alcohol/Ester Derivatives, Their Pesticidal Activities, and Investigation of Mechanisms of Action against Tetranychus cinnabarinus. Journal of Agricultural and Food Chemistry , 2018, 66( 49): 12898-12910.
6) Lv Min, Liu, Guangci, Jia Minghong, Xu Hui*. Synthesis of matrinic amide derivatives containing 1,3,4-thiadiazole scaffold as insecticidal/acaricidal agents. Bioorganic Chemistry , 2018, 81: 88-92.
7) Kong Wenlong, Bao Yinhe, Ma Qianjun, Xu Hui*. Synthesis and biological activities of novel pyrazolomatrine derivatives. Bioorganic & Medicinal Chemistry Letters ,2018,28(20): 3338-3341.
8) Yang Ruige, Lv Min, Xu Hui*. Synthesis of Piperine Analogs Containing Isoxazoline/Pyrazoline Scaffold and Their Pesticidal Bioactivities. J ournal of A gricultural and F ood C hemistry , 2018, 66: 11254-11264.
9) Huang Jiulin, Lv Min, Thapa Sunita, Xu Hui*. Synthesis of novel quinolinomatrine derivatives and their insecticidal/ acaricidal activities. Bioorganic & Medicinal Chemistry Letters , 2018, 28(10): 1753-1757.
10) Yang Ruige, Guo Yong, Zhang Yuanyuan, Xu Hui*. Semisynthesis of new ethers from furyl-ring-based acylation derivatives of fraxinellone as insecticidal agents against Mythimna separata Walker in vivo. Chinese Chemical Letters , 2018, 29(6): 995-997.
11) Yang Ruige, Zhang Yuanyuan, Xu Hui*. Synthesis of novel isoxazoline-containing podophyllotoxin/2'(2',6')-(di)halogenopodophyllotoxin derivatives and their insecticidal/acaricidal activities. Bioorganic & Medicinal Chemistry Letters , 2018, 28(8): 1410-1416.
12) Huang Xiaobo, Zhang Bingchuan, Xu Hui*. Synthesis of andrographolide-related esters as insecticidal and acaricidal agents. Bioorganic & Medicinal Chemistry Letters , 2018,28(3): 360-364.
13) Lv Min, Ma Jingchun, Li Qin, Xu Hui*. Discovery of benzotriazole-azo-phenol/aniline derivatives as antifungal agents. Bioorganic & Medicinal Chemistry Letters , 2018, 28(2): 181-187.
14) Zhiqiang Sun, Min Lv, Xiang Yu, Hui Xu,* Application of sustainable natural bioresources in crop protection: insight into a podophyllotoxin-derived botanical pesticide for regulating insect vestigial wing of Mythimna separata Walker. ACS Sustainable Chemistry & Engineering , 2017, 5, 3945-3954.
15) Zhi, Xiaoyan; Zhang, Yuanyuan; Huang, Jiulin ; Hui Xu,* Seven-Membered Lactam Derivatives of Podophyllotoxins as New Pesticidal Agents. S cientific R eports , 2017, 7, 3917.
16) Zhang, Yuanyuan; Hui Xu,* Recent progress in the chemistry and biology of limonoids. RSC Advances , 2017, 7 , 35191-35220.
17 Jiu-Lin Huang, Min Lv, Hui Xu,* Semisynthesis of some matrine ether derivatives as insecticidal agents. RSC Advances , 2017, 7 , 15997-16004.
18) Guo Yong, Yang Ruige, Xu Hui*. Semisynthesis of esters and oxime esters/sulfonates from furyl-ring-based acetylation derivatives of fraxinellone as insecticidal agents. RSC Advances , 2017, 7 , 28009-28015.
19) Jiulin Huang, Ming Xu, Shaochen Li, Jiani He, Hui Xu,* Synthesis of some ester derivatives of 4′-demethoxyepipodophyllotoxin/2′-chloro-4′-demethoxyepipodophyllotoxin as insecticidal agents against oriental armyworm, Mythimna separata Walker. Bioorganic & Medicinal Chemistry Letters , 2017, 27, 511-517.
20) Xiang Yu, Zhiping Che, Hui Xu,* Recent Advances in the Chemistry and Biology of Podophyllotoxins. C hemistry -A E uropean J ournal , 2017, 2 3 , 4467-4526.
21) Ruige Yang,Xiaobo Huang, Zhiping Che,Yuanyuan Zhang, Hui Xu,* Application of sustainable natural resources in crop protection: Podophyllotoxin-based botanical pesticides derived from Podophyllum hexandrum for controlling crop-threatening insect pests. Industrial Crops and Products . 2017, 107 , 45-53.
22) Xiaobo Huang,Bingchuan Zhang, Hui Xu,* Synthesis of some monosaccharide-related ester derivatives as insecticidal and acaricidal agents. Bioorganic & Medicinal Chemistry Letters , 2017, 27, 4336-4340.
23) Guo Yong, Yang Ruige, Xu Hui*. New Insecticidal Agents from Halogenation/Acylation of the Furyl-Ring of Fraxinellone. S cientific R eports , 2016, 6, 35321.
24) Yu Mingqiao, Liu Guangci, Zhang Yuanyuan, Feng Tao, Xu Ming, Xu Hui*. Design, Synthesis and Evaluation of Novel Isoxazolines/Oxime Sulfonates of 2 '(2 ', 6 ')-(Di) Chloropodophyllotoxins as Insecticidal Agents. S cientific R eports , 2016, 6, 33062.
25) Li Qin, Huang Xiaobo, Li Shaochen, Ma Jingchun, Lv Min*, Xu Hui*. Semisynthesis of Esters of Fraxinellone C4/10-Oxime and Their Pesticidal Activities. J ournal of A gricultural and F ood C hemistry , 2016, 64(27): 5472-5478.
26) Huang Jiulin, Xu Hui*. Matrine: Bioactivities and Structural Modifications. C urrent T opics in M edicinal C hemistry , 2016, 16(27): 3365-3378.
27) Xiang Yu, Feng Gang, Huang Jiulin, Hui Xu,* Evaluation of some quinoline-based hydrazone derivatives as insecticidal agents. RSC Advances , 2016, 6 , 30405-30411.
28) Chun Yang, Xiaoyan Zhi, Hui Xu.*Advances on semisynthesis, total synthesis, and structure-activity relationships of honokiol and magnolol derivatives. Mini-Reviews in Medicinal Chemistry, 2016, 16 , 404-426.
29) Chun Yang,Xiaoyan Zhi, Jie Li, Jing Zha, and Hui Xu,* Natural products-based insecticidal agents 20. Design, synthesis and insecticidal activity of novel honokiol/magnolol azo derivatives. Industrial Crops and Products . 2015, 76 , 761-767.
30) Lingling Fan, Xiaoyan Zhi, Zhiping Che, Hui Xu,* Insight into 2α-Chloro-2′(2′,6′)-(Di)Halogenopicropodophyllotoxins Reacting with Carboxylic Acids Mediated by BF3.Et2O.. Scientific Reports , 2015, 5, 16285.
31) Huan Qu, Min Lv, Xiang Yu, Xihong Lian, Hui Xu,* Discovery of Some Piperine-Based Phenylsulfonylhydrazone Derivatives as Potent Botanically Narcotic Agents. Scientific Reports , 2015, 5, 13077.
32) Rong Wang, Xiaoyan Zhi,Jie Li, Hui Xu,* Synthesis of Novel Oxime Sulfonate Derivatives of 2′(2′,6′)-(di)Chloropicropodophyllotoxins as Insecticidal Agents. Journal of Agricultural & Food Chem istry , 2015, 63 , 6668-6674.
33) Xiang Yu, Danfeng Shi, Xiaoyan Zhi, Qin Li, Xiaojun Yao, Hui Xu,* Synthesis and quantitative structure-activity relationship (QSAR) study of C7-oxime ester derivatives of obacunone as insecticidal agents. RSC A dvances , 2015, 40 , 31700-31707.
34) Xiang Yu, Xiaoyan Zhi, Guodong Ding, Hui Xu,*Insight into reduction of obacunone, and their ester derivatives as insecticidal agents against Mythimna separata Walker. Bioorganic & Medicinal Chemistry Letters , 2015, 25, 25-29.
35) Chun Yang, Xiaoyan Zhi, Hui Xu,*Synthesis of benzoxazole derivatives of honokiol as insecticidal agents against Mythimna separata Walker. Bioorganic & Medicinal Chemistry Letters , 2015, 25, 2217-2219.
36) Zhi, Xiaoyan; Yang, Chun; Yu, Xiang; Hui Xu,* Synthesis and insecticidal activity of new oxime derivatives ofpodophyllotoxin-based phenazines against Mythimna separat a Walker. Bioorganic & Medicinal Chemistry Letters , 2014, 24, 5679-5682.
37) Zhang, Yanhua; Yan, Yuanyuan; Chen, Suying; Gao, Zhinan; Hui Xu,* Naked-eye' quinoline-based 'reactive' sensor for recognition of Hg2+ ion in aqueous solution. Bioorganic & Medicinal Chemistry Letters , 2014, 24, 5373-5376.
38) Wang, Juanjuan; Yu, Xiang; Zhi, Xiaoyan; Hui Xu,* Synthesis and insecticidal activity of new deoxypodophyllotoxin derivatives modified in the D-ring. Bioorganic & Medicinal Chemistry Letters , 2014, 24, 4542-4545.
39) Zhi, Xiaoyan; Yu, Xiang; Yang, Chun; Ding, Guodong; Chen, Hui; Hui Xu,* Synthesis of 4 beta-acyloxypodophyllotoxin analogs modified in the C and E rings as insecticidal agents against Mythimna separata Walker. Bioorganic & Medicinal Chemistry Letters , 2014, 24, 765-772.
40) Wang, Yi; Yu, Xiang; Zhi, Xiaoyan; Xiao, Xiao; Yang, Chun; Hui Xu,* Synthesis and insecticidal activity of novel hydrazone compounds derived from a naturally occurring lignan podophyllotoxin against Mythimna separata (Walker). Bioorganic & Medicinal Chemistry Letters , 2014, 24, 2621-2624.
41) Lingling Fan, Yong Guo,Xiaoyan Zhi,Xiang Yu, Hui Xu,* Insecticidal Activity of Their Esters against Oriental Armyworm, Mythimna separat a Walker. Journal of Agricultural & Food Chem istry , 2014, 62 , 3726-3733.
42) Zhiping Che,Xiang Yu,Xiaoyan Zhi,Lingling Fan,Xiaojun Yao, Hui Xu,*Synthesis of Novel 4 alpha-(Acyloxy)-2'(2',6')-(di)halogenopodophyllotoxin Derivatives as Insecticidal Agents. Journal of Agricultural & Food Chem istry , 2013, 61 , 8148-8155.
43) Juanjuan Wang,Xiaoyan Zhi,Xiang Yu,and Hui Xu.* Synthesis and Insecticidal Activity of New Deoxypodophyllotoxin-Based Phenazine Analogs against Mythimna separata Walker. Journal of Agricultural & Food Chem istry , 2013, 61 , 6336-6343.
44) Zhiping Che,Shaoyong Zhang, Yonghua Shao,Lingling Fan,Hui Xu,* Xiang Yu,Xiaoyan Zhi,Xiaojun Yao, and Rui Zhang, Synthesis and Quantitative Structure-Activity Relationship (QSAR) Study of Novel N-Arylsulfonyl-3-Acylindole Arylcarbonyl Hydrazone Derivatives as Nematicidal Agents. Journal of Agricultural & Food Chem istry , 2013, 61 , 5696-5705.
45) Guo Y., Qu, H., Zhi, X. Y., Yu, X., Yang, C., Hui Xu,** Semisynthesis and insecticidal activity of some fraxinellone derivatives modified in the B ring. Journal of Agricultural & Food Chemistry , 2013， 61 , 11937-11944.
46) He Shuzhen, Shao Yonghua, Fan Lingling, Che Zhiping, Xu Hui,* Zhi Xiaoyan, Wang Juanjuan, Yao Xiaojun,* Qu Huan, Synthesis and quantitative structure−activity relationship (QSAR) study of novel 4-acyloxypodophyllotoxin derivatives modified in the A and C rings as insecticidal agents. Journal of Agricultural & Food Chem istry , 2013, 61 , 618-625.
47) Guo Yong, Fan Lingling, Wang Juanjuan, Yang Chun, Qu Huan, Xu Hui,* Stereoselective synthesis of 4α-acyloxy-2α/β-bromopodophyllotoxin derivatives as insecticidal agents. Tetrahedron , 2013, 69 , 774-781.
48) Huan Qu,Xiang Yu, Xiao-Yan Zhi, Min Lv, Hui Xu*. Natural-product-based insecticidal agents 14. Semisynthesis and insecticidal activity of new piperine-based hydrazone derivatives against Mythimna separata Walker in vivo. Bioorganic & Medicinal Chemistry Letters , 2013, 23, 5552-5557.
49) Zhiping Che,Xiang Yu,Lingling Fan, Hui Xu*. Insight into dihalogenation of E-ring of podophyllotoxins, and their acyloxyation derivatives at the C4 position as insecticidal agents. Bioorganic & Medicinal Chemistry Letters , 2013, 23, 5592-5598.
50) Chun Yang, Yonghua Shao, Xiao-Yan Zhi, Huan Qu, Xiang Yu,Xiaojun Yao, Hui Xu*. Semisynthesis and quantitative structure-activity relationship (QSAR) study of some cholesterol-based hydrazone derivatives as insecticidal agents. Bioorganic & Medicinal Chemistry Letters , 2013, 23, 4806-4812.
51) Yong Guo, Yuan-Yuan Yan, Xiao-Yan Zhi, Chun Yang, Hui Xu*. Phenanthroimidazole-based thiobenzamide as an effective sensor for highly selective detection of mercury(II). Bioorganic & Medicinal Chemistry Letters , 2013, 23, 3382-3384.
52) Yan Yuanyuan, Che Zhiping, Yu Xiang, Zhi Xiaoyan, Wang Juanjuan, Xu Hui*. Fluorescence 'on-off-on' chemosensor for sequential recognition of Fe3+ and Hg2+ in water based on tetraphenylethylene motif. Bioorg anic & Med icinal Chem istry , 2013, 21, 508-513.
53) Xiao-yan Zhi, Chun Yang, Rui Zhang, Ying Hu, Ya-zhen Ke, Hui Xu* Natural products-based insecticidal agents 13. Semisynthesis and insecticidal activity of novel phenazine derivatives of 4β-acyloxypodophyllotoxin modified in the E-ring against Mythimna s eparat a Walker in vivo. Industrial Crops and Products . 2013, 42 , 520-526.
54) Dai Huiling, Yan yuanyuan, Guo Yong, Fan Lingling, Che Zhiping, Xu Hui,*A selective and sensitive “turn-on” fluorescent chemosensor for recognition of Hg2+ ion in water. Chemistry-A European Journal , 2012, 18 , 11188-11191.
55) Guo Yong, Yan Yuanyuan, Yu Xiang, Wang Yi, Xu Hui,* Synthesis and insecticidal activity of some novel fraxinellone-based esters. Journal of Agricultural & Food Chem istry , 2012, 60 , 7016-7021.
56) Ling-ling Fan. Zhi-ping Che. Rui Zhang. Xiang Yu. Xiao-yan Zhi. Hui Xu,* Synthesis of benzopyrano[4,3-b](N-arylsulfonyl)indoles and benzopyrano[3,4-b](N-arylsulfonyl)indoles via intramolecular palladium-catalyzed aryl–aryl coupling reaction. Molecular Diversity , 2012, 16 , 415-421.
57) Yong Guo, Yuan-Yuan Yan, Chun Yang, Xiang Yu, Xiao-Yan Zhi, Hui Xu*.Regioselective synthesis of fraxinellone-based hydrazone derivatives as insecticidal agents. Bioorg anic & Med icinal Chem istry Lett ers , 2012, 22, 5384-5387.
58) Yi Wang, Yonghua Shao,Yangyang Wang,Lingling Fan, Xiang Yu, Xiaoyan Zhi,Chun Yang,Huan Qu,Xiaojun Yao,and Hui Xu*Synthesis and Quantitative Structure-Activity Relationship (QSAR) Study of Novel Isoxazoline and Oxime Derivatives of Podophyllotoxin as Insecticidal Agents. Journal of Agricultural & Food Chem istry , 2012, 60 , 8435-8443.
59) Xu Hui,* Wang Qingtian, Guo Yong, Stereoselective Synthesis of 4a-Alkyloxy-2-a/b-
Bromopodophyllotoxin Derivatives as Insecticidal Agents. Chemistry-A European Journal , 2011, 17 , 8299-8303.
60) Xu Hui,* Fan Ling-ling, Synthesis and antifungal activities of novel 5,6-dihydro-indolo[1,2-a]quinoxaline derivatives. European Journal of Med icinal Chem istry , 2011, 46 , 364-369.
61) Xu Hui,* Fan Ling-ling, Antifungal agents. Part 4: Synthesis and antifungal activities of novel indole[1,2-c]-1,2,4-benzotriazine derivatives against phytopathogenic fungi in vitro. European Journal of Med icinal Chem istry , 2011, 46 , 1919-1925.
62) Dai Huiling, Xu Hui,* A water-soluble 1,8-naphthalimide-based 'turn on' fluorescent chemosensor for selective and sensitive recognition of mercury ion in water. Bioorg anic & Med icinal Chem istry Lett ers , 2011, 21 , 5141-5144
63) Xu Hui,* Zhang jun-liang,Natural products-based insecticidal agents 9. Design, semisynthesis and insecticidal activity of 28-acyloxy derivatives of toosendanin against Mythimna separata Walker in vivo. Bioorg anic & Med icinal Chem istry Lett ers , 2011, 21 , 1974-1977.
64) Xu Hui,* Xiao X, Zhao X, Guo Y, Yao XY, Unexpectedly convenient and stereoselective synthesis of 4α-acyloxy-2-chloropodophyllotoxins in the presence of BF3.Et2O. Bioorg anic & Med icinal Chem istry Lett ers , 2011, 21 : 4008-4012.
65) Xu Hui,* Zhang jun-liang,Natural products-based insecticidal agents 11. Synthesis and insecticidal activity of novel 4 alpha-arylsulfonyloxybenzyloxy-2 beta-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo. Bioorg anic & Med icinal Chem istry Lett ers , 2011, 21 , 5177-5180.
66) Xu Hui,* Xiao Xiao, Wang, Qing-Tian, Natural products-based insecticidal agents 7. Semisynthesis and insecticidal activity of novel 4 alpha-alkyloxy-2-chloropodophyllotoxin derivatives against Mythimna separata Walker in vivo. Bioorg anic & Med icinal Chem istry Lett ers , 2010, 20 , 5009-5012.
67) Xu Hui,* Wang Juan-Juan, Natural products-based insecticidal agents 5. Design, semisynthesis and insecticidal activity of novel 4 '-substituted benzenesulfonate derivatives of 4-deoxypodophyllotoxin against Mythimna separata Walker in vivo. Bioorg anic & Med icinal Chem istry Lett ers , 2010, 20 , 2500-2502.
68) Xu Hui,* Wang Yang-Yang, Antifungal agents. Part 5: Synthesis and antifungal activities of aminoguanidine derivatives of N-arylsulfonyl-3-acylindoles. Bioorg anic & Med icinal Chem istry Lett ers , 2010, 20 , 7274-7277.
69) Xu Hui,* Zeng Xiwen, Synthesis of diaryl-azo derivatives as potential antifungal agents Bioorg anic & Med icinal Chem istry Lett ers , 2010, 20 , 4193-4195.
70) Xu Hui,* He Xiaoqiang, Natural products-based insecticidal agents 6. Design, semisynthesis, and insecticidal activity of novel monomethyl phthalate derivatives of podophyllotoxin against Mythimna separata Walker in vivo. Bioorg anic & Med icinal Chem istry Lett ers , 2010, 20 , 4503-4506.
71) Xu Hui,* Lv Min, Tian Xuan, A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007 . Curr ent Med icinal Chem istry , 2009, 1 6 (3), 327-349.
72) Xu Hui,* Wang Juan-Juan, Sun Hui-Jun, Lv Min, Tian Xuan, Yao Xiao-Jun, Zhang Xing, Semisynthesis and Quantitative Structure-Activity Relationship (QSAR) Study of Novel Aromatic Esters of 4 '-Demethyl-4-deoxypodophyllotoxin as Insecticidal Agents. Journal of Agricultural & Food Chem istry , 2009, 57( 1 7) , 7919-7923.
73) Xu Hui,* Xiao Xiao. Natural products-based insecticidal agents 4. Semisynthesis and insecticidal activity of novel esters of 2-chloropodophyllotoxin against Mythimna separata Walker in vivo. Bioorg anic & Med icinal Chem istry Lett ers , 2009, 19 , 5415-5418.
74) Lv Min, Xu Hui,* Dipyridodiazepinone Analogs as Human Immunodeficiency Virus Type 1-Specific Non-Nucleoside Reverse Transcriptase Inhibitors: An Overview Curr ent Med icinal Chem istry , 2010, 1 7 (18), 1874-1898.
75) Xu Hui,* Lv Min. Developments of Indoles as Anti-HIV-1 Inhibitors Current Pharmaceutical Design , 2009, 15 , 2120-2148.
76) Xu Hui,* Overview of Naphthalimide Analogs as Anticancer Agents Curr ent Med icinal Chem istry , 2009, 1 6 (36), 4797-4813.
5．联系方式
通讯地址：陕西杨凌西农路22号 西北农林科技大学植保学院农药设计及合成实验室
邮编：712100
联系电话：029-87091952
E-mail: orgxhzjyy@126.com.
